Endocrine Abstracts

Testosterone deficiency is common in men with type 2 diabetes (T2D) and cardiovascular diseases (CVD), such as atherosclerosis. Previous studies have shown that testosterone replacement improves several cardiovascular risk factors including insulin resistance, glycaemic control, cholesterol and inflammation. The mechanisms by which testosterone mediates these effects are unknown. LXR, a nuclear receptor also regulates these cardiovascular risk factors and the atheroprotective ...

The transplacental passage of thyroid hormones (TH) from the maternal to fetal circulations is important for normal fetal development, particularly the fetal central nervous system. This is particularly so before the onset of endogenous fetal TH production from the second trimester of pregnancy. The human hemochorial placenta regulates the quantity of TH passing through and the complement of the different forms of TH to ensure requisite levels are present in the fetus for each...